Blar i forfatter "Skaare, Dagfinn"
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Antimicrobial susceptibility testing of Bacteroides species by disk diffusion: The NordicAST Bacteroides study
Stubhaug, Tore Taksdal; Giske, Christian G.; Justesen, Ulrik S; Kahlmeter, Gunnar; Matuschek, Erika; Sundsfjord, Arnfinn; Skaare, Dagfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-28)Objectives - Antimicrobial susceptibility testing (AST) of anaerobic bacteria has until recently been done by MIC methods. We have carried out a multi-centre evaluation of the newly validated EUCAST disk diffusion method for AST of Bacteroides spp.<p> <p>Methods - A panel of 30 Bacteroides strains was assembled based on reference agar dilution MICs, resistance gene detection and quantification ... -
Characterization and Fitness Cost of Tn7100, a Novel Integrative and Conjugative Element Conferring Multidrug Resistance in Haemophilus influenzae
Johannessen, Helene; Anthonisen, Inger Lill; Zecic, Nermin; Hegstad, Kristin; Ranheim, Trond Egil; Skaare, Dagfinn (Journal article; Tidsskriftartikkel, 2022-07-22)A multidrug-resistant (MDR) strain of Haemophilus influenzae, Hi-228, with phenotypic resistance toward ampicillin, cefotaxime, chloramphenicol, gentamicin, and azithromycin, was isolated in Oslo, Norway. The strain was part of a clonal outbreak (2016–2017) comprising five ST143 strains with identical resistotypes. Hi-228 carries a novel integrative and conjugative element (ICE), Tn7100, contributing ... -
Emergence of clonally related multidrug resistant haemophilus influenzae with penicillin-binding protein 3-mediated resistance to extended-spectrum cephalosporins, Norway, 2006 to 2013
Skaare, Dagfinn; Anthonisen, Inger Lill; Kahlmeter, Gunnar; Matuschek, Erika; Natås, Olav Bjarte; Steinbakk, Martin; Sundsfjord, Arnfinn; Kristiansen, Bjørn-Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Multilocus sequence typing and ftsI sequencing: a powerful tool for surveillance of penicillin-binding protein 3-mediated beta-lactam resistance in nontypeable Haemophilus influenzae
Skaare, Dagfinn; Anthonisen, Inger Lill; Caugant, Dominique A; Jenkins, Andrew; Steinbakk, Martin; Strand, Linda; Sundsfjord, Arnfinn; Tveten, Yngvar; Kristiansen, Bjørn-Erik (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)Background Beta-lactam resistance in Haemophilus influenzae due to ftsI mutations causing altered penicillin-binding protein 3 (PBP3) is increasing worldwide. Low-level resistant isolates with the N526K substitution (group II low-rPBP3) predominate in most geographical regions, while high-level resistant isolates with the additional S385T substitution (group III high-rPBP3) are common in Japan ... -
Non-beta-lactamase-mediated beta-lactam resistance in Haemophilus influenzae. Mechanisms, epidemiology and susceptibility testing
Skaare, Dagfinn (Doctoral thesis; Doktorgradsavhandling, 2016-05-20)Haemophilus influenzae is a major pathogen, with the ability to cause a wide spectrum of invasive and non-invasive infections. Beta-lactams are first-line drugs but beta- lactam resistant strains are common. Beta-lactamase (bla) producing isolates emerged in the 1970s, and non-bla-mediated resistance due to mutations in the ftsI gene encoding penicillin-binding protein 3, denoted ‘rPBP3’ in this ... -
Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae
Hegstad, Kristin; Mylvaganam, Haima; Janice, Jessin; Josefsen, Ellen H.; Sivertsen, Audun; Skaare, Dagfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-29)<i>Haemophilus influenzae</i> colonizes the respiratory tract in humans and causes both invasive and noninvasive infections. Resistance to extended-spectrum cephalosporins in <i>H. influenzae</i> is rare in Europe. In this study, we defined acquired resistance gene loci and <i>ftsI</i> mutations in multidrug-resistant (MDR) and/or PBP3-mediated beta-lactam-resistant (rPBP3) <i>H. influenzae</i> ...